- Younger sister of Gretchen Barretto and Marjorie Barretto. Elder sister, Gia, is a teacher in Boston, MA.
- Sister-in-law of Dennis Padilla.
- Had a strained relationship with the family of Rico Yan after the death of the young actor in March 29, 2002. She was partly blamed for the untimely death of the actor whom she had a long relationship.
- Shares the same birth date with husband, Raymart Santiago - 20 July.
- She was 13 when Douglas Quijano discovered her in a party. Her two sisters (Gretchen and Marjorie) were both in the movies already and she wanted to follow their footsteps.
- Ex-sister-in-law of Rowell Santiago, Randy Santiago, Raymart Santiago and Reily Pablo L. Santiago Jr..
- Parents: Miguel Alvir Barretto and Estrella Castelo Barretto.
- Adopted baby girl Sabrina, a year before she married Raymart Santiago.
- Named Most Popular Movie/Teen Star of the Year 2000 by Starlight Cultural Foundation.
- Named Queen of RP Movies 2004, for 'Milan (2004)' by Guillermo Mendoza Scholarship Foundation.
- Named Favorite Stylish Leading Lady 2004 by MTV Style Awards.
- Declared Box Office Queen 2003 (for 'Kailangan Kita (2003)') by Guillermo Mendoza Scholarship Foundation.
- German Moreno Youth Achievement Award, 2003.
- Tightened her security after a stalking fan tried to kidnap her daughter Sabrina March 3, 2009. Charged with the crime, fan Joanne Castro pleaded guilty to a lesser crime of unjust vexation and got a five-day prison term and a $100 fine which Claudine later protested.
- Has a son named her ex-husband Rodrigo Santino with Raymart Santiago.
- At the Cinema One Originals Film Festival 2009, she received the Cinema One Legend Award.
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