This film marks the longest gap between Despicable Me films. The gap between Despicable Me (2010) & Despicable Me 2 (2013) was 3 years, the gap between Despicable Me 2 & Despicable Me 3 (2017) was 4 years and the gap between Despicable Me 3 & Despicable Me 4 (2024) is 7 years.
The film is releasing on the 11th anniversary of Despicable Me 2 (2013).
Will Ferrell (Maxime Le Mal) previously starred in Megamind (2010), which released the same year as the first Despicable Me film and also has a villain protagonist.
This is the first Illumination film to be rated PG for thematic elements.