- Did comedic improv for 10 years and participated in the Canadian Improv Games.
- Her Emmy win in 2016 for Outstanding Lead Actress in a TV series for Orphan Black (2013) set a precedent for the number of characters she portrayed: "Sarah/Alison/Cosima/Helena/Rachel and M.K., Krystal".
- She was taught by her mother to speak German before learning English. Her grandparents also spoke German around her when she was a child. Even though she is a little out of practice today, she is still able to recite certain phrases.
- She has Ukrainian, Polish, Romanian, Austrian, and German ancestry.
- Counts Gena Rowlands's harrowing performance in A Woman Under the Influence (1974) as the role that most influenced her to seriously pursue a career in acting.
- She was on the shortlist of actresses who auditioned for the role of Rose in Star Wars: The Last Jedi.
- Nominated for the 2018 Emmy Award in the Lead Actress in a Drama Series category for her various roles in Orphan Black (2013), but lost to Claire Foy from The Crown (2016).
- An alumna of the Canadian Improv Games
- Announced her marriage to Brendan Hines on The Late Show with Stephen Colbert on August 11, 2022.
- Such is her enthusiasm for cycling, Tatiana actually had her mountain bike transported from her Los Angeles home to New York for her Off-Broadway debut run in Tracy Letts' "Mary Page Marlowe" (June 2018).
- Her Emmy win in 2016 for Outstanding Lead Actress in a TV series for Orphan Black (2013) set a precedent for the number of characters she portrayed: "Sarah/Alison/Cosima/Helena/Rachel/M.K./Krystal and Beth".
- Has two younger brothers named Daniel and Michael.
- Her brother Daniel Maslany's wife is actress Lucy Hill.
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