Harrison Ford replaces the late William Hurt as Thaddeus Ross, making this Ford's first appearance in the Marvel Cinematic Universe. This also marks the sixth time a role was recast in the MCU, after:
- Don Cheadle as War Machine, replaced Terrence Howard
- Mark Ruffalo as Hulk, replaced Edward Norton
- Zachary Levi as Fandral, replaced Josh Dallas
- Ross Marquand as Red Skull, replaced Hugo Weaving
- Kathryn Newton as teenage Cassie Lang, replaced Emma Fuhrmann
Will be Tim Blake Nelson and Liv Tyler's first Marvel Cinematic Universe film in 17 years as Samuel Sterns/The Leader and Betty Ross respectively, after having last appeared in The Incredible Hulk (2008).
Harrison Ford's second comic book movie, after Cowboys & Aliens (2011). He was also considered to play Batman in Batman (1989) and Dick Tracy in Dick Tracy (1990).
Originally titled Captain America: New World Order, but was changed due to the term's association with antisemitic conspiracy theories.